Moving one DNA double helix through another by a type II DNA topoisomerase: the story of a simple molecular machine.
نویسنده
چکیده
. . Transporting one DNA double helix through another . The clamp model: a type II DNA topoisomerase as an ATP-modulated protein clamp . The number of gates in the protein clamp . Three-dimensional structures of type II DNA topoisomerase fragments . How are the various subfragments connected? . A molecular model of DNA transport by a type II DNA topoisomerase
منابع مشابه
Topo2008: DNA Topoisomerases in Biology and Medicine
The DNA topoisomerases are a group of fascinating enzymes that play an essential but dangerous game with DNA. They break and rejoin either one or both strands of the double helix to solve the problems of tangling and linking that occur as a result of DNA manipulations (replication, transcription and recombination) in all cells. This basic problem with the DNA structure was recognized by Watson ...
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Type II topoisomerases resolve topological problems of DNA double helices by passing one duplex through the reversible double-stranded break they generated on another duplex. Despite the wealth of information in the cleaving operation, molecular understanding of the enzymatic DNA ligation remains elusive. Topoisomerase poisons are widely used in anti-cancer and anti-bacterial therapy and have b...
متن کاملTopoisomerase Inhibitors and Types of Them
Objective: In this paper, we have introduced topoisomerase inhibitors, mechanism of action and types of them. DNA topoisomerases are ubiquitous enzymes that catalyze essential enzymes to solve the topological problems accompanying key nuclear processes such as DNA replication, transcription, repair and chromatin assembly by introducing temporary single or double strand breaks in the DNA. Result...
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Objective: In this paper, we have introduced topoisomerase inhibitors, mechanism of action and types of them. DNA topoisomerases are ubiquitous enzymes that catalyze essential enzymes to solve the topological problems accompanying key nuclear processes such as DNA replication, transcription, repair and chromatin assembly by introducing temporary single or double strand breaks in the DNA. Result...
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Topoisomerase II constitutes a family of nuclear enzymes essential to all living cells. These enzymes are capable of transferring one DNA double helix through a transient break in another DNA double helix. Type II topoisomerases play important roles in DNA metabolic processes, in which they are involved in DNA replication, transcription, chromosome condensation and de-condensation. Topoisomeras...
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ورودعنوان ژورنال:
- Quarterly reviews of biophysics
دوره 31 2 شماره
صفحات -
تاریخ انتشار 1998